Phenotypically Varying P270 Protein of Type II T. vaginalis isolates (C20A3, 270-kDa)

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Monoclonal antibody to a major surface immunogen differentiates isolates and subpopulations of Trichomonas vaginalis.
MAb led to the discovery of two distinct isolate types of T. vaginalis: heterogeneous phenotypically-varying (PV) Type II and homogeneous, non-phenotypically varying Type I.
The discovery that non-fluorescent Type II isolate organisms and non-fluorescent Type I organisms adhered and killed host epithelial cells. The fluorescent organisms express P270 on surface and are non-adherent.
The discovery that the MAb C20A3 showed 95+ percent of in vivo trichomonads from women were negative phenotype (no P270 on surface of parasites)
The discovery that only phenotypically varying Type II detected by MAb C20A3 were infected with dsRNA viruses.
The discovery that it was a “repertoire” of high molecular weight proteins that underwent phenotypic variation in a coordinated fashion.
The discovery that the protein P270 had many repeated protein segments, each containing the identical DREGRD epitope detected by C20A3.
The discovery that the phenotypic variation was under the control of iron.

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Monoclonal antibody to a major surface immunogen differentiates isolates and subpopulations of Trichomonas vaginalis.
MAb led to the discovery of two distinct isolate types of T. vaginalis: heterogeneous phenotypically-varying (PV) Type II and homogeneous, non-phenotypically varying Type I.
The discovery that non-fluorescent Type II isolate organisms and non-fluorescent Type I organisms adhered and killed host epithelial cells. The fluorescent organisms express P270 on surface and are non-adherent.
The discovery that the MAb C20A3 showed 95+ percent of in vivo trichomonads from women were negative phenotype (no P270 on surface of parasites)
The discovery that only phenotypically varying Type II detected by MAb C20A3 were infected with dsRNA viruses.
The discovery that it was a “repertoire” of high molecular weight proteins that underwent phenotypic variation in a coordinated fashion.
The discovery that the protein P270 had many repeated protein segments, each containing the identical DREGRD epitope detected by C20A3.
The discovery that the phenotypic variation was under the control of iron.

Monoclonal antibody to a major surface immunogen differentiates isolates and subpopulations of Trichomonas vaginalis.
MAb led to the discovery of two distinct isolate types of T. vaginalis: heterogeneous phenotypically-varying (PV) Type II and homogeneous, non-phenotypically varying Type I.
The discovery that non-fluorescent Type II isolate organisms and non-fluorescent Type I organisms adhered and killed host epithelial cells. The fluorescent organisms express P270 on surface and are non-adherent.
The discovery that the MAb C20A3 showed 95+ percent of in vivo trichomonads from women were negative phenotype (no P270 on surface of parasites)
The discovery that only phenotypically varying Type II detected by MAb C20A3 were infected with dsRNA viruses.
The discovery that it was a “repertoire” of high molecular weight proteins that underwent phenotypic variation in a coordinated fashion.
The discovery that the protein P270 had many repeated protein segments, each containing the identical DREGRD epitope detected by C20A3.
The discovery that the phenotypic variation was under the control of iron.